Thymosin alpha 1 (thymalfasin) is a synthetic, N terminally acetylated 28 amino acid peptide derived from prothymosin alpha, with the sequence Ac Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr Lys Asp Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn OH. It is studied as an immunomodulatory peptide that can engage innate immune signaling pathways, including toll like receptor associated mechanisms reported in experimental models. Thymosin alpha 1 is used in research investigating dendritic cell activation, T cell associated signaling, and cytokine network regulation in vitro and preclinical systems.

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